GLOBAL RESEARCH SYNDICATE
No Result
View All Result
  • Login
  • Latest News
  • Consumer Research
  • Survey Research
  • Marketing Research
  • Industry Research
  • Data Collection
  • More
    • Data Analysis
    • Market Insights
  • Latest News
  • Consumer Research
  • Survey Research
  • Marketing Research
  • Industry Research
  • Data Collection
  • More
    • Data Analysis
    • Market Insights
No Result
View All Result
globalresearchsyndicate
No Result
View All Result
Home Data Analysis

Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis

globalresearchsyndicate by globalresearchsyndicate
December 18, 2019
in Data Analysis
0
Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis
0
SHARES
8
VIEWS
Share on FacebookShare on Twitter

  • 1.

    Grivennikov, S. I., Greten, F. R. & Karin, M. Immunity, inflammation, and cancer. Cell 140, 883–899 (2010).

  • 2.

    Hunter, P. The inflammation theory of disease. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment. EMBO Rep. 13, 968–970 (2012).

  • 3.

    Nathan, C. & Ding, A. Nonresolving inflammation. Cell 140, 871–882 (2010).

  • 4.

    Jaiswal, S. et al. Age-related clonal hematopoiesis associated with adverse outcomes. N. Engl. J. Med. 371, 2488–2498 (2014).

  • 5.

    Martincorena, I. et al. Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin. Science 348, 880–886 (2015).

  • 6.

    Yokoyama, A. et al. Age-related remodelling of oesophageal epithelia by mutated cancer drivers. Nature 565, 312–317 (2019).

  • 7.

    Burisch, J., Jess, T., Martinato, M. & Lakatos, P. L. The burden of inflammatory bowel disease in Europe. J. Crohns Colitis 7, 322–337 (2013).

  • 8.

    Ungaro, R., Mehandru, S., Allen, P. B., Peyrin-Biroulet, L. & Colombel, J. F. Ulcerative colitis. Lancet 389, 1756–1770 (2017).

  • 9.

    Eaden, J. A., Abrams, K. R. & Mayberry, J. F. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut 48, 526–535 (2001).

  • 10.

    Kang, H. & Shibata, D. Direct measurements of human colon crypt stem cell niche genetic fidelity: the role of chance in non-Darwinian mutation selection. Front. Oncol. 3, 264 (2013).

  • 11.

    Choi, C. R., Bakir, I. A., Hart, A. L. & Graham, T. A. Clonal evolution of colorectal cancer in IBD. Nat. Rev. Gastroenterol. Hepatol. 14, 218–229 (2017).

  • 12.

    Eto, A., Muta, T., Yamazaki, S. & Takeshige, K. Essential roles for NF-κB and a Toll/IL-1 receptor domain-specific signal(s) in the induction of IκB-ζ. Biochem. Biophys. Res. Commun. 301, 495–501 (2003).

  • 13.

    Yamamoto, M. et al. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ. Nature 430, 218–222 (2004).

  • 14.

    Bruno, M. E. C., Frantz, A. L., Rogier, E. W., Johansen, F. E. & Kaetzel, C. S. Regulation of the polymeric immunoglobulin receptor by the classical and alternative NF-κB pathways in intestinal epithelial cells. Mucosal Immunol. 4, 468–478 (2011).

  • 15.

    Cao, A. T., Yao, S., Gong, B., Elson, C. O. & Cong, Y. Th17 cells upregulate polymeric Ig receptor and intestinal IgA and contribute to intestinal homeostasis. J. Immunol. 189, 4666–4673 (2012).

  • 16.

    Bruno, M. E. et al. Correlation of biomarker expression in colonic mucosa with disease phenotype in Crohn’s disease and ulcerative colitis. Dig. Dis. Sci. 60, 2976–2984 (2015).

  • 17.

    Nakatsuka, Y. et al. Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia. Mucosal Immunol. 11, 1203–1218 (2018).

  • 18.

    Mino, T. et al. Regnase-1 and Roquin regulate a common element in inflammatory mRNAs by spatiotemporally distinct mechanisms. Cell 161, 1058–1073 (2015).

  • 19.

    Iwasaki, H. et al. The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1. Nat. Immunol. 12, 1167–1175 (2011).

  • 20.

    Reznik, B., Clement, S. L. & Lykke-Andersen, J. hnRNP F complexes with tristetraprolin and stimulates ARE-mRNA decay. PLoS One 9, e100992 (2014).

  • 21.

    Ramirez-Carrozzi, V. et al. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat. Immunol. 12, 1159–1166 (2011).

  • 22.

    Robles, A. I. et al. Whole-exome sequencing analyses of inflammatory bowel disease-associated colorectal cancers. Gastroenterology 150, 931–943 (2016).

  • 23.

    Fujita, M. et al. Genomic landscape of colitis-associated cancer indicates the impact of chronic inflammation and its stratification by mutations in the Wnt signaling. Oncotarget 9, 969–981 (2018).

  • 24.

    Din, S. et al. Mutational analysis identifies therapeutic biomarkers in inflammatory bowel disease-associated colorectal cancers. Clin. Cancer Res. https://doi.org/10.1158/1078-0432.CCR-17-3713 (2018).

  • 25.

    Baker, A. M. et al. Evolutionary history of human colitis-associated colorectal cancer. Gut 68, 985–995 (2019).

  • 26.

    Jostins, L. et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491, 119–124 (2012).

  • 27.

    Liu, J. Z. et al. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat. Genet. 47, 979–986 (2015).

  • 28.

    Riddell, R. H. et al. Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum. Pathol. 14, 931–968 (1983).

  • 29.

    Yoshida, K. et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature 478, 64–69 (2011).

  • 30.

    Shiraishi, Y. et al. An empirical Bayesian framework for somatic mutation detection from cancer genome sequencing data. Nucleic Acids Res. 41, e89 (2013).

  • 31.

    Okuma, A. et al. Enhanced apoptosis by disruption of the STAT3-IκB-ζ signaling pathway in epithelial cells induces Sjögren’s syndrome-like autoimmune disease. Immunity 38, 450–460 (2013).

  • 32.

    el Marjou, F. et al. Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis 39, 186–193 (2004).

  • 33.

    Miyoshi, H. & Stappenbeck, T. S. In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture. Nat. Protoc. 8, 2471–2482 (2013).

  • 34.

    Katakura, K. et al. Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. J. Clin. Invest. 115, 695–702 (2005).

  • 35.

    Chen, K. et al. IL-17 Receptor signaling in the lung epithelium is required for mucosal chemokine gradients and pulmonary host defense against K. pneumoniae. Cell Host Microbe 20, 596–605 (2016).

  • 36.

    Johansen, C. et al. IκBζ is a key driver in the development of psoriasis. Proc. Natl Acad. Sci. USA 112, E5825–E5833 (2015).

  • 37.

    Müller, A. et al. IκBζ is a key transcriptional regulator of IL-36-driven psoriasis-related gene expression in keratinocytes. Proc. Natl Acad. Sci. USA 115, 10088–10093 (2018).

  • 38.

    Hildebrand, D. G. et al. IκBζ is a transcriptional key regulator of CCL2/MCP-1. J. Immunol. 190, 4812–4820 (2013).

  • 39.

    Goto, N. et al. Distinct roles of Hes1 in normal stem cells and tumor stem-like cells of the intestine. Cancer Res. 77, 3442–3454 (2017).

  • 40.

    Blokzijl, F. et al. Tissue-specific mutation accumulation in human adult stem cells during life. Nature 538, 260–264 (2016).

  • Related Posts

    How Machine Learning has impacted Consumer Behaviour and Analysis
    Consumer Research

    How Machine Learning has impacted Consumer Behaviour and Analysis

    January 4, 2024
    Market Research The Ultimate Weapon for Business Success
    Consumer Research

    Market Research: The Ultimate Weapon for Business Success

    June 22, 2023
    Unveiling the Hidden Power of Market Research A Game Changer
    Consumer Research

    Unveiling the Hidden Power of Market Research: A Game Changer

    June 2, 2023
    7 Secrets of Market Research Gurus That Will Blow Your Mind
    Consumer Research

    7 Secrets of Market Research Gurus That Will Blow Your Mind

    May 8, 2023
    The Shocking Truth About Market Research Revealed!
    Consumer Research

    The Shocking Truth About Market Research: Revealed!

    April 25, 2023
    market research, primary research, secondary research, market research trends, market research news,
    Consumer Research

    Quantitative vs. Qualitative Research. How to choose the Right Research Method for Your Business Needs

    March 14, 2023
    Next Post
    Repsol commissions dual-purpose seismic survey offshore Malaysia

    Repsol commissions dual-purpose seismic survey offshore Malaysia

    Categories

    • Consumer Research
    • Data Analysis
    • Data Collection
    • Industry Research
    • Latest News
    • Market Insights
    • Marketing Research
    • Survey Research
    • Uncategorized

    Recent Posts

    • Ipsos Revolutionizes the Global Market Research Landscape
    • How Machine Learning has impacted Consumer Behaviour and Analysis
    • Market Research: The Ultimate Weapon for Business Success
    • Privacy Policy
    • Terms of Use
    • Antispam
    • DMCA

    Copyright © 2024 Globalresearchsyndicate.com

    Welcome Back!

    Login to your account below

    Forgotten Password?

    Retrieve your password

    Please enter your username or email address to reset your password.

    Log In
    This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Cookie settingsACCEPT
    Privacy & Cookies Policy

    Privacy Overview

    This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience.
    Necessary
    Always Enabled
    Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
    Non-necessary
    Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.
    SAVE & ACCEPT
    No Result
    View All Result
    • Latest News
    • Consumer Research
    • Survey Research
    • Marketing Research
    • Industry Research
    • Data Collection
    • More
      • Data Analysis
      • Market Insights

    Copyright © 2024 Globalresearchsyndicate.com